Within our specialty areas of cardiovascular, metabolic disease and dermatology we have strong clinical trial experience in a range of indications. This expertise enables us to identify the best sites and effectively recruit trial subjects for the individual indications, as well as provide insightful feasibility analyses and contingency planning. So, no matter the specific indication within cardiovascular, metabolic diseases and dermatology, Integrium can anticipate trial-specific challenges and handle them successfully, whether at home or abroad.

Cardiovascular and Metabolic Disease Experience

• Acute coronary syndromes

• Diabetes

• Angina

• Growth disorders

• Arrhythmia

• Hyperlipidemia

• Atherosclerosis

• Hypertension

• Cardiomyopathy

• Metabolic syndrome

• Chronic heart failure

• Stroke

Dermatology Experience

• Acne vulgaris

• Head lice

• Actinic keratosis

• Herpetic infections

• Aesthetic dermal filler

• Melasma

• Alopecia

• Onychomycosis

• Atopic dermatitis

• Photodamage including lentigines

• Basal cell carcinoma

• Psoriasis

• Dermatophyte infections

• Rosacea

• Genital warts

Wound Healing Experience

Closing the Gap in Wound Healing Trials

• At Integrium, we understand the complexities and challenges of wound healing.

• Our dedicated team of investigators, project managers, biostatisticians and medical writers is experienced in the design, conduct and analysis of clinical trials to evaluate interventions intended to speed and improve wound healing and reduce scarring.

• We work with key opinion leaders in dermatology, general surgery, burn surgery, plastic surgery, vascular surgery and podiatry.

Our clinical team has researched many types of acute and chronic wounds of various tissue types including:

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• Diabetic foot ulcers

• Venous Stasis Ulcers

• Decubitus Ulcers

• Lower Extremity Ulcers

• Dehisced Wounds

• Deep Partial Thickness Burns

• Partial Thickness Burns

• Compassionate Use (Neonatal Premature Infant)

• Auto-grafting and Donor Sites in Burn Patients

• Toxic Epidermal Necrolysis (TENS)

• Acute Wounds

• Surgical Wounds

• Epidermolysis Bullosa

• Hand Contractures

Dedicated Project Managers ensure:

• ​Proper preparation and placement of product to optimize wound healing

• Effective training in debridement and wound care

• Precise and accurate wound healing imaging and measurement

• Correct interpretation of complete epithelialization to ensure standardization of research sites

We have experience with a broad range of therapies and interventions including:

• Tissue Engineered Products

• Living Skin Equivalents

• Regenerative Medicine

• Cryopreserved Products

• Cell Cultured Products

• Dermal Substitutes

• Platelet Derived Growth Factors (PDGF)

• Topical Gels

• Anti-microbial Dressings

• Hyperbaric Oxygen Chambers

• Off Loading Devices

• Silhouette Mobile TM Device

We accurately assess and stage the wound healing process, wound closure and scarring.

We know how to use multiple wound assessment methods including surrogate endpoints and biomarkers, to increase the reliability and validity of results:

• Wound Healing Measurements

• Digital Photography

• Wound Tracing and Analysis

• Wound Scarring Scales

• Vancouver Scar Scale

• Visual Analog Scale